Basic Information

Strain Name
C57BL/6-Fcgrttm1Bcgen/Bcgen
Common Name
B-FcRn KO mice
Background
C57BL/6N
Catalog number
110165
Related Gene
FCGRT(Fc fragment of IgG receptor and transporter)
NCBI Gene ID

Gene targeting strategy

Gene targeting strategy for B-FcRn KO mice. Exons 1-5 of the mouse Fcgrt gene were knocked out in B-Fcrn KO mice.

mRNA expression analysis

Fcgrt gene expression analysis in wild-type and B-FcRn KO mice by RT-PCR. Kidney tissue was isolated from wild-type C57BL/6 (+/+) and homozygous B-FcRn KO (-/-) mice. Mouse Fcgrt mRNA was detected in wild-type mice but not in homozygous B-FcRn KO mice.

Protein expression analysis

FcRn protein expression analysis in wild-type and homozygous B-FcRn KO mice. Kidney tissue was isolated from wild-type C57BL/6 (+/+) and homozygous B-FcRn KO (-/-) mice and analyzed by western blot using an anti-mouse FcRn antibody. Mouse FcRn protein was detected in wild-type mice but not in B-FcRn KO mice.

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