Basic Information

Strain Name
C57BL/6-Itgavtm1(ITGAV)/Bcgen
Common Name
B-hITGAV mice
Background
C57BL/6
Catalog number
110866
Related Gene
integrin subunit alpha V, CD51, MSK8, VNRA, VTNR
NCBI Gene ID

Targeting strategy

Gene targeting strategy for B-hITGAV mice.

The exons 1-30 of mouse Itgav gene were replaced by human ITGAV exons 1-30 in B-hITGAV mice.

Protein expression analysis

Strain specific ITGAV expression analysis in heterozygous B-hITGAV mice by flow cytometry.

Bone marrow cells were collected from C57BL/6 wild-type mice (+/+) and heterozygous B-hITGAV mice(H/+) and analyzed by flow cytometry with species-specific anti-ITGAV antibody. Mouse ITGAV was detectable in wild-type mice and heterozygous B-hITGAV mice. Human ITGAV was exclusively detectable in heterozygous B-hITGAV mice.