Basic Information
Strain Name
C57BL/6-Retntm1(RETN)Bcgen/Bcgen
Common Name
B-hRETN mice
Background
C57BL/6
Catalog Number
112361
NCBI Gene ID
Related Genes
RETN: ADSF; RENT; RSTN; XCP1; FIZZ3; RETN1
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Targeting strategy
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Gene targeting strategy for B-hRETN mice.
Exons 1-5 of the mouse Retn gene, which encodes the full-length protein, was replaced by human RETN exons 1~4 in B-hRETN mice.
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Protein expression analysis
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Strain specific resistin expression analysis in homozygous B-hRETN mice by ELISA. Serum samples were collected from wild-type mice C57BL/6 mice (+/+) and homozygous B-hRETN mice (H/H), and analyzed by ELISA with species-specific resistin ELISA kit. Mouse resistin was detectable in wild-type mice (A). Human resistin was detectable in homozygous B-hRETN mice but not in wild-type mice (B).
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Summary
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Protein expression analysis:
Human RETN was only detectable in serum of homozygous B-hRETN mice, and mouse RETN was detectable only in wild-type C57BL/6 mice.
