Basic Information
Strain name
C57BL/6N-Timp1tm1(TIMP1)/Bcgen
Common Name
B-hTIMP1 mice
Background
C57BL/6N
Catalog Number
112339
Aliases
TIMP1(CLGI, EPA, EPO, HCI, TIMP, TIMP-1)
NCBI Gene ID
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Targeting strategy
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Gene targeting strategy for B-hTIMP1 mice.
The exons 2-6 of mouse Timp1 gene that encode the full-length protein, not including signal peptide were replaced by human TIMP1 exons 2-6 in B-hTIMP1 mice.
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Protein expression analysis
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Strain specific TIMP1 protein expression analysis in homozygous B-hTIMP1 mice by ELISA. Serum was collected from wild-type mice (+/+) and homozygous B-hTIMP1 mice(H/H), and analyzed by ELISA with species-specific TIMP1 ELISA kit. Mouse TIMP1 was detectable in wild-type mice. Human TIMP1 was exclusively detectable in homozygous B-hTIMP1 mice.
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Summary
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Protein expression analysis:
Human TIMP1 was exclusively detectable in homozygous B-hTIMP1 mice, and mouse TIMP1 was detectable only in wild-type mice.
