Basic Information

Strain Name
C57BL/6-Hipp1tm2(MUP-uPA)/Bcgen
Common Name
B-MUP-uPA mice
Background
C57BL/6
Catalog number
112036
NCBI Gene ID

Targeting strategy

Gene targeting strategy. The mouse uPA CDS driven by the Mup promoter, which was specific expression in the liver, was inserted into the mouse Hipp11 locus.

Mouse uPA mRNA expression analysis by RT-qPCR

Mouse uPA expression analysis in B-MUP-uPA mice by RT-qPCR. Liver and kidney tissues were isolated from wild-type C57BL/6 (+/+) and heterozygous B-MUP-uPA (H/+) mice (n=3, female, 9-week-old). Mouse uPA mRNA was expressed in the liver of heterozygous B-MUP-uPA mice and the level was higher than that in wild-type mice.

ALT and AST concentrations in serum

Serum ALT and AST analysis in B-MUP-uPA mice. Serum was collected from wild-type C57BL/6 (+/+) and heterozygous B-MUP-uPA (H/+) mice (n=10, male, 10-week-old). Serum ALT and AST concentrations were normal in B-MUP-uPA mice at 3 weeks of age, but elevated at 5 weeks, indicative of liver injury in B-MUP-uPA mice.

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