AACR 2024: Establishment of a humanized IL5/IL5RA mouse model to evaluate modulators of eosinophilic inflammation in vivo
Used in the poster: B-hIL5/hIL5RA mice
Summary:
IL-5/IL-5R signaling is crucial for eosinophil function and has therapeutic implications for inflammatory diseases like asthma. We developed a humanized B-hIL5/hIL5RA mouse model to assess IL-5/IL5R-targeting therapies. Successful generation of the model was confirmed, and stimulation with human IL5 increased eosinophil proportions in the blood, validating functionality. In an asthma-like disease model, treatment with mepolizumab or benralizumab analog significantly reduced eosinophil numbers in bronchioalveolar fluid and lung tissue, highlighting the model’s utility for testing human IL-5/IL-5RA modulators.
