Basic Information
Strain Name
NOD.CB17-PrkdcscidIl2rgtm1Fcgrttm1(FCGRT)/Bcgen
Common Name
B-NDG hFcRn mice
Background
B-NDG
Catalog number
111922
Related Genes
FCGRT (Fc fragment of IgG receptor and transporter)
NCBI Gene ID
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Targeting strategy
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Gene targeting strategy for B-NDG hFcRn mice.
The human full-length FCGRT cDNA sequence was inserted in the Fcgrt exon2 of B-NDG mice.
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Protein expression analysis
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Strain specific analysis of FcRn expression in B-NDG(+/+) and B-NDG hFcRn mice by western blot.
Liver, kidney and spleen were collected from B-NDG mice (+/+) and homozygous B-NDG hFcRn mice (H/H) and analyzed by western blot with species-specific anti-FcRn antibody. Mouse FcRn was detectable in B-NDG mice (+/+). Human FcRn was detectable only in homozygous B-NDG hFcRn mice (H/H) but not in B-NDG mice (+/+).
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Related Products
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Product name Product No. B-NDG hALB/hFcRn mice 112774 B-hFcRn mice 110001 B-FcRn KO mice 110165 B-hALB/hFcRn mice 121805 B-hCD40/hFcRn mice 111912 -
Summary
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Protein expression：
Mouse FcRn was detectable in B-NDG mice (+/+). Human FcRn was detectable only in homozygous B-NDG hFcRn mice (H/H) but not in B-NDG mice (+/+).
