Basic Information
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Protein expression analysis
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Strain specific analysis of FcRn expression in B-NDG(+/+) and B-NDG hFcRn mice by western blot.Liver, kidney and spleen were collected from B-NDG mice (+/+) and homozygous B-NDG hFcRn mice (H/H) and analyzed by western blot with species-specific anti-FcRn antibody. Mouse FcRn was detectable in B-NDG mice (+/+). Human FcRn was detectable only in homozygous B-NDG hFcRn mice (H/H) but not in B-NDG mice (+/+).
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Serum half-life of antibody drug in B-NDG hFcRn mice
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Pharmacokinetics of YERVOY-analog (isotype: human IgG1) in B-NDG hFcRn mice.B-NDG mice and B-NDG hFcRn mice were intravenously injected with YERVOY (in house), the isotype of YERVOY (in house) is human IgG1, and serum was collected for pharmacokinetic (PK) analysis (n=3). A, The PK curve. B, The PK parameters. Data are shown in mean ± SEM.
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Related Products
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Product name Product No. B-NDG hALB/hFcRn mice 112774 B-hFcRn mice 110001 B-FcRn KO mice 110165 B-hALB/hFcRn mice 121805 B-hCD40/hFcRn mice 111912 -
Summary
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Protein expression：
Mouse FcRn was detectable in B-NDG mice (+/+). Human FcRn was detectable only in homozygous B-NDG hFcRn mice (H/H) but not in B-NDG mice (+/+).
