Basic Information

Strain Name
NOD.CB17-PrkdcscidIl2rgtm1Fcgrttm1(FCGRT)/Bcgen
Common Name
B-NDG hFcRn mice
Background
B-NDG
Catalog number
111922
Related Genes
FCGRT (Fc fragment of IgG receptor and transporter)
NCBI Gene ID

Targeting strategy

Gene targeting strategy for B-NDG hFcRn mice. 

The human full-length FCGRT cDNA sequence was inserted in the Fcgrt exon2 of B-NDG mice.

Protein expression analysis

Strain specific analysis of FcRn expression in B-NDG(+/+) and B-NDG hFcRn mice by western blot.

Liver, kidney and spleen were collected from B-NDG mice (+/+) and homozygous B-NDG hFcRn mice (H/H) and analyzed by western blot with species-specific anti-FcRn antibody. Mouse FcRn was detectable in B-NDG mice (+/+). Human FcRn was detectable only in homozygous B-NDG hFcRn mice (H/H)  but not in B-NDG mice (+/+).

Related Products

Product name Product No.
B-NDG hALB/hFcRn mice  112774
B-hFcRn mice  110001
B-FcRn KO mice  110165
B-hALB/hFcRn mice  121805
B-hCD40/hFcRn mice  111912

Summary

Protein expression:

Mouse FcRn was detectable in B-NDG mice (+/+). Human FcRn was detectable only in homozygous B-NDG hFcRn mice (H/H)  but not in B-NDG mice (+/+).

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