Cre(ERT2) Knockin
CreERT2 inducible mouse model
Cre protein mediates a specific deletion of loxP flanked (floxed) DNA fragment. Therefore, the Cre mouse model allows tissue-specific gene Knockout based on the promoter. The ERT2 sequence is estrogen receptor targeting motif, whose nuclear translocation and activity are controlled by Tamoxifen, so that the tight and inducible regulation of Cre activity is realized by tamoxifen administration.
