Generation and Validation of Humanized GARP/TGFB1 Mice for Testing Novel Anti-human GARP Antibodies
SUMMARY Protein expression analysis: Human GARP and TGFB1 proteins were exclusively detected in homozygous B-hGARP/hTGFB1 mice, while mouse GARP and TGFB1 proteins were detected in…
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Humanized NKP46 Mouse Models for Testing Novel NK Cell-based Immunotherapies
Protein expression analysis: Human NKP46 protein was exclusively co-expressed with NK markers in B-hNKP46 mice. Leukocytes profile: Percentages of T, B, NK cells, monocyte/macrophages, and…
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AACR 2023: BCG008, A Human Siglec-15 Blocking Antibody, Displays Potent Anti-Tumor Activity in Siglec-15-Humanized Mice
Conclusions BCG008 is a novel, fully human anti-SIGLEC-15 antibody generated from RenMabTM mice BCG008 has higher hSIGLEC-15 & fasSIGLEC-15 affinity and recognizes a different epitope…
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AACR 2023: A Novel EGFR x MUC1 Bispecific Antibody-Drug Conjugate, BSA01, Targets MUC1 Transmembrane Cleavage Products and Improves Tumor Selectivity
Conclusions Co-expression of EGFR and MUC1 in multiple solid tumors suggests that simultaneous targeting of EGFR and MUC1 with bsADC has the potential to enhance…
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AACR 2023: 1C3, A Novel Non-Blocking Anti-Human TNFR2 Antibody, Promotes Effector T Cell Responses and Demonstrates Potent Anti-Tumor Activity
Conclusions BCG003 binds to the CRD3 and CRD4 domains of TNFR2 without blocking the binding of TNFα. In vitro, BCG003 stimulates the proliferation and activation…
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AACR 2023: The RenMice HiTS (Hyperimmune Target Specific) Platform Facilitates Identification of Novel Therapeutic Antibodies for Challenging Targets
Conclusions In conclusion, the RenMice™ HiTS (Hyperimmune Target Specific) Platform enables accelerated identification of fully human antibodies with increased diversity of antibody paratopes and species…
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AACR 2023: Novel Humanized CD36 Mouse Model for Therapeutic Studies
Used in the poster: B-hCD36 mice Conclusions mRNA expression analysis: Mouse Cd36 mRNA was detected in lung tissue isolated from wild-type mice, while human CD36…
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AACR 2023: In vivo Efficacy Evaluation of Anti-Human VEGFR2 Antibodies in Humanized B-hVEGFR2 Mice
Used in the poster: B-hVEGFR2 mice Conclusions mRNA expression analysis: Murine Vegfr2 mRNA was detected in embryonic tissue isolated from wild-type mice, while human…
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AACR 2023: Humanized OX40/OX40L Mice as a Tool for Evaluating Novel Therapeutics
Used in the poster: B-hOX40/hOX40L mice Conclusions mRNA expression analysis: Mouse Ox40l mRNA was detected in dendritic cells isolated from wild-type mice, while human OX40L…
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AACR 2023: Generation of Humanized TREM2 Mice for Preclinical Evaluation of Therapeutics Targeting Tumor-Associated Macrophages
Used in the poster: B-hTREM2 mice Conclusions Murine Trem2 mRNA was detected in wild-type mice, while human TREM2 mRNA was detected in homozygous B-hTREM2 mice…
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AACR 2023: Development of MHC I/II Knock-Out Immunodeficient Mouse Strains for Alleviating GvHD Induced by Human PBMC Reconstitution
Used in the poster: B-NDG MHC I/II DKO mice plus Conclusions We have generated an immunodeficient model, B-NDG MHC I/II DKO mice plus, that lacks…
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AACR 2023: Development of Immunodeficient Mice Expressing Human IL3, GM-CSF, CSF1 and THPO for Improved Human Myeloid and Lymphoid Cell Reconstitution
Used in the poster: B-NDG MGMT3 mice Conclusions We generated an immunodeficient (B-NDG) mouse model containing human GM-CSF, CSF1, THPO, and IL3 in place of…
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