B-hCD39 mice

May 31, 2020

CD39, nucleoside triphosphate diphosphohydrolase-1 (NTPDase 1), is an ectoenzyme that degrades ATP to AMP. It is a member of ectonucleoside triphosphate dihydrolases (E-NTPDases) which are involved in regulation of extracellular nucleotide catabolism and controlling the extracellular nucleoside triphosphate pool (NTP). CD39 is the dominant member of this family in the immune system and involved in […]

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B-hIL2RB mice

May 12, 2020

Interleukin-2 receptor subunit beta is a type I membrane protein that in humans is encoded by the CD122 gene, also known as IL2RB, IL15RB and P70-75. The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form […]

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B-hIL2RG mice

May 8, 2020

CD132 is a 64-70 kD type I transmembrane glycoprotein of the Ig superfamily, and is also known as common γ chain (γc) or IL-2 receptor γ subunit. It is expressed broadly on T- and B-lymphocytes, NK cells, monocytes, and granulocytes. CD132 is an essential component of cytokine receptors for IL-2, IL-4, IL-7, IL-9, IL-15, and […]

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B-CAG-GFP cKI rats

March 27, 2020

These GFPcK Irats knockin rats have a floxed-STOP cassette preventing expression of the downstream bicistronic sequence (3*GFP). Although under control of a CAG promoter, widespread expression of GFP is prevented by the STOP cassette. After exposure to Cre recombinase, expression of GFP will be observed.

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