B-IL2rg KO rats
May 21, 2019
The Il2rg KO rat was developed using targeted TALEN technology in the Sprague-Dawley strain. This model possesses a 14 bp deletion within Exon 2 of IL2rg on chromosome X. This strain was maintained by mating homozygous males with homozygous females on a Sprague-Dawley genetic background.
B-Ldlr KO rats
May 20, 2019
The Low Density Lipoprotein (LDL) Receptor is a cell-surface receptor presented in clathrin-coated pits that mediates the endocytosis of LDL, the major cholesterol-carrying lipoprotein of plasma. Loss of Ldlr function leads to accumulation of excess LDL in the blood, leading to elevated serum cholesterol, especially when fed a high fat diet, which makes Ldlr knockout […]
B-Pink1 KO rats
May 20, 2019
Pink1 KO rats were developed using CRISPR/Cas9 technology in the Sprague-Dawley strain. Two sgRNAs were designed to generate a ~6.5kb chromosomal deletion spanning exons 2-4 of the Pink1 locus in the rat genome. As a result, the majority of the coding region of Pink1 is knocked out. This strain was maintained by mating homozygous males […]
B-Rag2 KO rats
May 20, 2019
The recombinant-activating gene 2 (Rag2) plays an important role in the rearrangement and recombination of the genes of immunoglobulin and T cell receptor molecules during the initiation of V(D)J recombination. Loss of Rag2 protein leads to no mature T and B cells, the critical components of the adaptive immune system. This rat can be used […]
B-Apoe KO mice
May 20, 2019
B-p53 KO rats
May 20, 2019
Tp53tm1/Bcgen rats are a useful model for studying tumor formation, screening in vivo carcinogenicity, and examining the efficacy of therapeutic agents. The Tp53 KO rat model was developed using targeted TALEN technology in the Sprague-Dawley strain. This model possesses a 12 bp deletion and 2 bp insertion within Exon 2 of Tp53 on chromosome 10. […]
B-SDG rats
May 20, 2019
The recombinant-activating gene 2 (Rag2) plays an important role in the rearrangement and recombination of the genes of immunoglobulin and T cell receptor molecules during the initiation of V(D)J recombination. Loss of Rag2 protein leads to no mature T and B cells, the critical components of the adaptive immune system. Il2rg is known as the […]
