AACR 2023: 1C3, A Novel Non-Blocking Anti-Human TNFR2 Antibody, Promotes Effector T Cell Responses and Demonstrates Potent Anti-Tumor Activity
Conclusions BCG003 binds to the CRD3 and CRD4 domains of TNFR2 without blocking the binding of TNFα. In vitro, BCG003 stimulates the proliferation and activation…
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AACR 2023: The RenMice HiTS (Hyperimmune Target Specific) Platform Facilitates Identification of Novel Therapeutic Antibodies for Challenging Targets
Conclusions In conclusion, the RenMice™ HiTS (Hyperimmune Target Specific) Platform enables accelerated identification of fully human antibodies with increased diversity of antibody paratopes and species…
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AACR 2023: Novel Humanized CD36 Mouse Model for Therapeutic Studies
Used in the poster: B-hCD36 mice Conclusions mRNA expression analysis: Mouse Cd36 mRNA was detected in lung tissue isolated from wild-type mice, while human CD36…
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AACR 2023: In vivo Efficacy Evaluation of Anti-Human VEGFR2 Antibodies in Humanized B-hVEGFR2 Mice
Used in the poster: B-hVEGFR2 mice Conclusions mRNA expression analysis: Murine Vegfr2 mRNA was detected in embryonic tissue isolated from wild-type mice, while human…
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AACR 2023: Humanized OX40/OX40L Mice as a Tool for Evaluating Novel Therapeutics
Used in the poster: B-hOX40/hOX40L mice Conclusions mRNA expression analysis: Mouse Ox40l mRNA was detected in dendritic cells isolated from wild-type mice, while human OX40L…
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AACR 2023: Generation of Humanized TREM2 Mice for Preclinical Evaluation of Therapeutics Targeting Tumor-Associated Macrophages
Used in the poster: B-hTREM2 mice Conclusions Murine Trem2 mRNA was detected in wild-type mice, while human TREM2 mRNA was detected in homozygous B-hTREM2 mice…
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AACR 2023: Development of MHC I/II Knock-Out Immunodeficient Mouse Strains for Alleviating GvHD Induced by Human PBMC Reconstitution
Used in the poster: B-NDG MHC I/II DKO mice plus Conclusions We have generated an immunodeficient model, B-NDG MHC I/II DKO mice plus, that lacks…
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AACR 2023: Development of Immunodeficient Mice Expressing Human IL3, GM-CSF, CSF1 and THPO for Improved Human Myeloid and Lymphoid Cell Reconstitution
Used in the poster: B-NDG MGMT3 mice Conclusions We generated an immunodeficient (B-NDG) mouse model containing human GM-CSF, CSF1, THPO, and IL3 in place of…
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AACR 2023: Discovery of BCG033, A Novel Anti-PTK7 x TROP2 Bispecific Antibody-Drug Conjugate with Promising Efficacy Against Triple-Negative Breast Cancer
Conclusions BCG033 is a novel and fully human bispecific PTK7 and TROP2 antibody-drug conjugate generated from the RenLite® platform. Cytotoxicity assays and internalization assays indicate…
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AACR 2023: BCG022: A Novel Bispecific Antibody-Drug Conjugate Targeting HER3 and MET
Conclusions BCG022 is a novel and fully human bispecific antibody-drug conjugate generated from the RenLite® platform that exhibits cross-species reactivity to human and cynomolgus monkey…
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