SITC 2023: BCG022: A HER3×MET Bispecific Antibody-drug Conjugate (BsADC) Targeting Key Mechanisms of Bypass Resistance in Multiple Tumor Types
SUMMARY HER3 and MET were co-expressed in various tumor types, and their signaling plays a key role in EGFR TKI drug resistance. HER3×MET bsAbs generated…
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Preclinical CD3-based Mouse Models for Evaluation of Bi-specific T-cell Engager Antibodies
SUMMARY mRNA and protein expression analysis: Human Cd3e mRNA was exclusively detected B-hCD3E mice and human Cd3e, Cd3d, Cd3g mRNAs were exclusively detected in B-hCD3EDG…
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Humanized ICOS Mice as a Novel Tool for Predicting and Monitoring T-cell-mediated Immunotherapy Response
SUMMARY mRNA expression analysis: Mouse Icos mRNA was detected in thymic tissue isolated from wild-type and heterozygous B-hICOS (H/+) mice. Human ICOS mRNA was detected…
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A Novel B2m-deficient Immunodeficient Model Expressing Human IL15 for Preclinical Evaluation of T Cell and NK Cell-based Therapies
CONCLUSION We have generated B-NDG B2m plus/hIL15 mice, a highly immunodeficient mouse model lacking MHC I and expressing IL-15 for improved NK cell engraftment. …
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Development of a Preclinical CD98HC Mouse Model for Therapeutic Studies
SUMMARY • mRNA expression analysis: Mouse Cd98 mRNA was detected in kidney tissue from wild-type mice, while human CD98 mRNA was detected in B-hCD98HC mice.…
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Humanized CD200/CD200R Mice as a Tool for Evaluating Novel Therapeutics
SUMMARY Protein expression analysis: Mouse CD200 protein was detected in wild-type C57BL/6 (+/+) mice, while human CD200 protein was detected in homozygous B-hCD200/hCD200R (H/H) mice.…
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Generation and Validation of Humanized GARP/TGFB1 Mice for Testing Novel Anti-human GARP Antibodies
SUMMARY Protein expression analysis: Human GARP and TGFB1 proteins were exclusively detected in homozygous B-hGARP/hTGFB1 mice, while mouse GARP and TGFB1 proteins were detected in…
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Humanized NKP46 Mouse Models for Testing Novel NK Cell-based Immunotherapies
Protein expression analysis: Human NKP46 protein was exclusively co-expressed with NK markers in B-hNKP46 mice. Leukocytes profile: Percentages of T, B, NK cells, monocyte/macrophages, and…
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AACR 2023: BCG008, A Human Siglec-15 Blocking Antibody, Displays Potent Anti-Tumor Activity in Siglec-15-Humanized Mice
Conclusions BCG008 is a novel, fully human anti-SIGLEC-15 antibody generated from RenMabTM mice BCG008 has higher hSIGLEC-15 & fasSIGLEC-15 affinity and recognizes a different epitope…
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AACR 2023: A Novel EGFR x MUC1 Bispecific Antibody-Drug Conjugate, BSA01, Targets MUC1 Transmembrane Cleavage Products and Improves Tumor Selectivity
Conclusions Co-expression of EGFR and MUC1 in multiple solid tumors suggests that simultaneous targeting of EGFR and MUC1 with bsADC has the potential to enhance…
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