AACR 2022: Developing a Translational Tool for GLP-1-Based Therapeutic Agonists in Humanized GLP1R Mice
mRNA and protein expression analysis: Human GLP1R mRNA was exclusively detected in the lung of homozygous B-hGLP1R mice compared to wild-type mice by RT-PCR. Similarly,…
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AACR 2022: Evaluating Delivery of TFR1-targeting Therapies to the CNS in a Novel Humanized TFR1 Mouse Model
Conclusions Human TFR1 expression was analyzed in homozygous B-hTFR1 mice by flow cytometry and RT-PCR. When compared with wild type mice, there were no abnormalities…
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AACR 2021: Humanized IL17A/IL17F mouse model provides a preclinical tool for the evaluation of therapeutic drugs targeting to IL-17 pathway
Expression of the proinflammatory cytokine interleukin 17 (IL-17) by activated CD4+ T cells has been associated with autoimmune disease pathogenesis. Biocytogen generated a double humanized…
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AACR 2021: Humanized CCR8 Mouse Model Provides A Translational Tool For Anti-Human CCR8 Antibody Drug Development
CCR8 plays a critical role in Treg-mediated immunosuppression, indicating CCR8 is a promising target for anti-tumor drug development. Biocytogen generated a humanized B-hCCR8 mouse model…
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AACR 2021: Humanized IL6/hIL6R mouse model supports the evaluation of therapeutic drug candidates targeting human IL6 and IL6 receptor
Interleukin 6 (IL-6) is a pleiotropic cytokine that not only plays an important role in the immune response, but has also been associated with the…
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AACR 2021: Anti-GCGR in vivo efficacy evaluated in a new humanized hGCGR mouse model
Binding of glucagon to its receptor, GCGR, results in an increase in intracellular cAMP levels, which plays a role in promoting glycogenolysis and gluconeogenesis, altogether…
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AACR 2021: Humanized B-hC5AR1 mouse model for evaluation of anti-C5AR1 mAb in vivo efficacy
Activated myeloid-derived suppressor cells upregulate C5AR1 expression, which plays a significant role in inhibiting T cell-related responses. Increased cancer cell invasion and growth by the…
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AACR 2021: Novel Engineered B-NDG B2M KO Mice Plus Shows Delayed GvHD response and Favorable GvL Immune Profiling After hPBMC Engraftment
B-NDG B2M KO mice plus exhibit immunodeficient phenotypes, in which T, B, and NK cells are defective with some histopathological changes in lymphoid organs. B-NDG…
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AACR 2021: Improved LAG-3 humanized knock-in mouse model for assessment of mono- and combination therapy strategies for cancer treatment
LAG-3 is a negative regulator of immunity, such that inhibition of LAG-3 enhances the anti-tumor effect of specific CD8+ T cells. Biocytogen generated a humanized…
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AACR 2021: Double-humanized 4-1BB/4-1BBL mouse is an advanced model for liver toxicity and efficacy evaluation of 4-1BB therapeutic antibodies
4-1BB signaling results in increased cytotoxic T lymphocyte (CTL) activity, cytokine induction, and prevention of activation-induced cell death (AICD). Biocytogen generated a double humanized B-h4-1BB/h4-1BBL…
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