B-hHVEM MC38
May 21, 2019
B-hCEACAM1 MC38
May 21, 2019
The mouse Ceacam1 gene was replaced by human CEACAM1 coding sequence in B-hCEACAM1 MC38 cells. Human CEACAM1 is highly expressed on the surface of B-hCEACAM1 MC38 cells.
B-Drd2-Cre Rats
May 21, 2019
The Drd2 gene encodes dopamine receptor D2. In this strain, Cre recombinase expression is under the control of Drd2 promoter. When crossed with a strain containing a loxP site-flanked sequence of interest, Cre-mediated recombination results in deletion of the flanked sequence in Drd2 expressing cells.
B-hPD-L1 MC38
May 21, 2019
The mouse Pdl1 gene was replaced by human PD-L1 coding sequence in B-hPD-L1 MC38 cells. Human PD-L1 is highly expressed on the surface of B-hPD-L1 MC38 cells.
B-Apoe KO rats
May 21, 2019
The Apoe KO rat was developed using targeted TALEN technology in the Sprague-Dawley strain. This model possesses a 13 bp deletion within Exon 3 on chromosome 1. This strain was maintained by mating homozygous males with homozygous females on a Sprague-Dawley genetic background.
B-IL2rg KO rats
May 21, 2019
The Il2rg KO rat was developed using targeted TALEN technology in the Sprague-Dawley strain. This model possesses a 14 bp deletion within Exon 2 of IL2rg on chromosome X. This strain was maintained by mating homozygous males with homozygous females on a Sprague-Dawley genetic background.
B-Ldlr KO rats
May 20, 2019
The Low Density Lipoprotein (LDL) Receptor is a cell-surface receptor presented in clathrin-coated pits that mediates the endocytosis of LDL, the major cholesterol-carrying lipoprotein of plasma. Loss of Ldlr function leads to accumulation of excess LDL in the blood, leading to elevated serum cholesterol, especially when fed a high fat diet, which makes Ldlr knockout […]
B-Pink1 KO rats
May 20, 2019
Pink1 KO rats were developed using CRISPR/Cas9 technology in the Sprague-Dawley strain. Two sgRNAs were designed to generate a ~6.5kb chromosomal deletion spanning exons 2-4 of the Pink1 locus in the rat genome. As a result, the majority of the coding region of Pink1 is knocked out. This strain was maintained by mating homozygous males […]
B-Rag2 KO rats
May 20, 2019
The recombinant-activating gene 2 (Rag2) plays an important role in the rearrangement and recombination of the genes of immunoglobulin and T cell receptor molecules during the initiation of V(D)J recombination. Loss of Rag2 protein leads to no mature T and B cells, the critical components of the adaptive immune system. This rat can be used […]
B-Apoe KO mice
May 20, 2019
