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    AACR 2024 Posters

    March 26, 2024
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    We are thrilled to have had the opportunity to attend the American Association for Cancer Research (AACR) Annual Meeting 2024 in San Diego, CA. Your interest in our research progress and the insightful discussions we had about your projects and objectives truly made our experience at AACR memorable. These exchanges are invaluable in advancing our collective efforts in cancer research.

    Below, you will find all of the poster presentations from the conference available for download!

     

    AACR 2024 Poster Presentations

    Off-the-Shelf Mouse Model Posters

    TargetRelated Model Poster Title (click to download)
    VEGFAB-hVEGFA miceDevelopment of humanized VEGFA models to assess preclinical efficacy of novel therapeutics in vivo
    TL1AB-hTL1A miceValidation of humanized TL1A mice for advancing preclinical research
    B-hCD3EDG/h4-1BBB-hCD3EDG/h4-1BB miceEstablishment of humanized CD3EDG/4-1BB mice for testing novel T cell engagers
    IL31/IL31RA/OSM/OSMRB-hIL31/hIL31RA/hOSM/hOSMR miceGeneration and validation of a novel humanized IL-31/IL-31RA/OSM/OSMR mouse model
    PD-1/PD-L1/CD94/NKG2AB-hPD-1/hPD-L1/hCD94/hNKG2A miceGeneration of humanized PD-1/PD-L1/CD94/NKG2A mice for evaluating novel combination therapies
    PD-1/PD-L1B-hPD-1/hPD-L1 miceTIL analysis demonstrates different mechanisms underlying PD-1 resistance in animal models
    IL5/IL5RAB-hIL5/hIL5RA miceEstablishment of a humanized IL5/IL5RA mouse model to evaluate modulators of eosinophilic inflammation in vivo
    NKP46B-hNKP46 miceA novel humanized NKP46 mouse model to support xenograft studies evaluating NK cell-based cancer immunotherapies
    RAG2/IL2RGB-SDG ratsGeneration of a novel severely immunodeficient Sprague Dawley rat model for xenograft studies
    B2M/HLA-A11.1/HLA-A24.2B-HLA-A11.1 mice

    B-HLA-A24.2 mice

    Development and validation of humanized HLA mouse model platforms for preclinical evaluation of novel peptide therapeutics
    CD16AB-hCD16A (CB-17 SCID) miceA novel humanized CD16A model to evaluate efficacy of human antibody therapeutics in triggering ADCC

    RenMabTM-Based Fully Human Antibody Assets

    RenLite®-derived Fully Human BsAb and BsADC Assets

    TargetsPlatformPoster Title (click to download)
    FOLR1/MUC1BsAb Discovery PlatformA first-in-class bispecific ADC targeting FOLR1 and MUC1 exhibits promising anti-tumor activity in a FOLR1low xenograft model
    EGFR/CD70BsAb Discovery PlatformBCG020, a novel bispecific antibody targeting EGFR and CD70, is effective against EGFR and CD70 high expressed tumors
    HER3/METBsAb Discovery PlatformBCG022, a novel HER3×MET bispecific antibody-drug conjugate (bsADC), demonstrates promising anti-tumor efficacy
    5T4/MUC1Bispecific ADC PlatformBCG016, a first-in-class bispecific antibody-drug conjugate targeting 5T4 and MUC1, demonstrates potent preclinical anti-tumor activity
    PTK7/TROP2Bispecific ADC PlatformBCG033, a novel bispecific antibody-drug conjugate targeting PTK7 and TROP2, demonstrates preclinical efficacy against triple-negative breast cancer and other solid tumor xenografts
    PTK7/EGFRBispecific ADC PlatformBCG017, a bispecific ADC targeting PTK7 and EGFR exhibits anti-tumor efficacy in PDX models
    EGFR/HER3Bispecific ADC PlatformA novel EGFR×HER3-targeting bispecific antibody drug-conjugate, BCG019, demonstrates robust anti-tumor efficacy in preclinical evaluation

    TCR-Mimic Antibody Assets

     

     

    Several collaborators of our RenBiologics Division presented at AACR 2024:

     

    Syncromune’s Oral Presentation:

    Our therapeutic antibody collaborator Syncromune delivered an oral presentation unveiling clinical data of its SYNC-T technology for the first time! The preliminary clinical results of SYNC-T SV-102, which features our clinical-stage CTLA-4 monoclonal antibody YH001 and CD40 agonistic monoclonal antibody YH003, have showcased an exceptional 85% overall response rate among patients battling metastatic castrate-resistant prostate cancer.

    AACR News Release | GlobeNewswire | AACR2024 Abstract

     

    CtM Bio’s Poster Presentation

    Title: A novel tri-specific T cell engager targeting the intracellular oncoprotein WT1

    AACR2024 Abstract

     


    The AACR Annual Meeting is the focal point of the cancer research community, where scientists, clinicians, other healthcare professionals, survivors, patients, and advocates gather to share the latest advances in cancer science and medicine. From population science and prevention; to cancer biology, translational, and clinical studies; to survivorship and advocacy; the AACR Annual Meeting highlights the work of the best minds in cancer research from institutions all over the world. (Source: AACR)