Basic Information

Strain Name
C57BL/6-Il1atm1(hILIA)/Bcgen
Stock Number
110073
Common Name
B-hIL1A mice
Source/Investigator
Bcgen (Beijing Biocytogen Co., Ltd)
Related Genes
IL1; IL-1A; IL1F1; IL1-ALPHA; IL-1 alpha
Species
C57BL/6
Appearance
Black
Genotypes
Heterozygous

Description

IL1A also known as hematopoietin 1 is a cytokine of the interleukin 1 family that in humans is encoded by the IL1A gene. In general, Interleukin 1 is responsible for the production of inflammation, as well as the promotion of fever and sepsis. IL-1A inhibitors are being developed to interrupt those processes and treat diseases. IL-1A is produced mainly by activated macrophages, as well as neutrophils, epithelial cells, and endothelial cells. It possesses metabolic, physiological, haematopoietic activities, and plays one of the central roles in the regulation of the immune responses. It binds to the interleukin-1 receptor.

Details

Protein expression analysis

Strain specific IL1A expression analysis in heterozygous B-hIL1A mice by ELISA. Cellular supernatant were collected from WT and heterozygous B-hIL1A mice stimulated with LPS in vivo, and analyzed by ELISA with species-specific IL1A ELISA kit. Mouse IL1A was detectable in WT mice and heterozygous B-hIL1A mice. Human IL1A was exclusively detectable in heterozygous B-hIL1A mice but not WT mice. ND, not detectable.

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